He studied the enlarged and enhanced pictures until he practically had them committed to memory, then he called Therri and asked to meet her again at the coffee shop. It's an antenna that could have been used to pick up signals.īack in his hotel room, he slipped the cassette out of the digital camera and into his laptop computer and brought the underwater pictures onto the screen. Austin dug into his jacket, pulled out the plastic disk he'd pried off the hull, and dropped it on the table.No pie in this plate. Therri furrowed her brow.Looks like a little pie plate. She jutted her chin forward as if she expected an argument.There's no one in that crew who would sabotage the ship. You've got me there, Austin said.If you could get into the ship and tear the engine room apart, maybe you'd find a mechanism that would allow the ship's speed to be controlled from the outside as well. So you do think someone from the outside could have sabotaged the ship. Did anyone else pack your baggage or has it been out of your sight? Let me ask what they say at airport security. She sat down and stared at the picture on the screen.What exactly am I looking at? Sorry, she said.I suppose I should keep an open mind about someone from the crew being involved.
I think it's a mechanism to override or bypass the steering controls from the bridge.You're sure of this?Reasonably certain. Someone outside the ship could have controlled the steering. This electrical connection runs up the side of the ship to a receiver above the waterline.
#Karen nuclear time series
He clicked the computer mouse through a series of pictures that showed the boxes welded to the hull from different angles.These housings could cover winches that can pull the rudder in either direction or lock it in place. It was in dry dock for four days in the Shetland Islands. “Assembling a Gene Regulatory Network for Specification of the B Cell Fate.” Developmental Cell 7, 607-617.Now that you mention it, she said without hesitation,the ship needed some engine work. Medina, KL, Pongubala, JMR, Reddy KL, Lancki DW, DeKoter R, Kieslinger M, Grosschedl R, Singh H. “Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5.” Nature Immunology 6, 836-843. Reynaud D, DeMarco I, Reddy KL, Schjerven H, Bertolino E, Smale ST, Winandy S, Singh HS (2008) “Key features of pro-B cells are specifically regulated by Ikaros.” Nature Immunology.īertolino E, Reddy K, Medina KL, Parganas E, Ihle J, and Singh H (2005). (2008) “Mammalian gene repression mediated by inducible repositioning to the nuclear membrane.” Nature, 452(7184): 243-7 Reddy, KL, Zullo, JM, Bertolino E, Singh, HS. (2008).“The Role of Nuclear Localization in Regulating Tcrb Recombination and Allelic Exclusion.” Nature Immunology. Reddy KL, Schlimgen R, Singh HS, Krangel M. (2008) Signaling and transcriptional control coordinating V(D)J recombination and B cell development” "V(D)J Recombination", edited by Dr. “Using molecular tethering to analyze the role of nuclear compartmentalization in the regulation of mammalian gene activity.” Methods. Specifically, they are trying to understand how genes are regulated at the nuclear periphery, decipher how genes are localized (or “addressed”) to specific nuclear compartments and, finally, determine how these processes are utilized in development and corrupted in disease.
The impact of architectural and cellular organization of genomes on gene activity is a next step to unlocking genetic and epigenetic mechanisms in development and disease. Understanding the cell biology of genomes and how nuclear architecture controls gene expression is necessary to truly understand biological processes such as development and disease.Īlthough sequencing of the genome and comparative genome analysis have yielded insights into the regulation and dis-regulation of genetic information, these efforts shed little light into how genomes actually work in vivo.
The focus of the research in the Reddy lab is to begin to understand how the nuclear periphery and other subcompartments contribute to general nuclear architecture and to specific gene regulation.
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